Proof that whole plant CBD makes better medicine!

If you're a wholesale customer of Highgarden Farm you have probably heard these words from me; "I decided to use the entire plant (sans the stalk) because, while i can't prove it, i think there are compounds in the hemp that we don't fully understand but are highly medicinal".  Or something to that affect. 1

Well we finally have our proof! 2 Thanks to the wonderful folks in Israel who once again are leading the charge in CBD research we now know that our hunch was correct.

The scientists obtained a CBD-rich strain called “Avidekel” from Tikkun Olam, an Israeli medical marijuana producer. Referred to as “clone 202” in this study, Avidekel has hardly any THC and therefore is not intoxicating.

The Israeli researchers extracted CBD-rich oil from clone 202. The extract—consisting of 17.9 percent CBD, 1.1 percent THC, 1.1 percent cannabichromene (CBC), 0.2 percent cannabigerol (CBG), and “traces” of cannabinol (CBN) and cannabivarol (CBDV)—was given to mice to evaluate its anti-inflammatory and painkilling effect.

For comparative purposes, the scientists administered pure CBD to another group of mice and assessed its anti-inflammatory and analgesic properties. They also compared the extent to which single-molecule CBD and whole plant CBD inhibited the production of tumor necrosis factor alpha (TNFa), a systemic inflammatory signaling molecule. Dysregulation of TNF-alpha production has been implicated in several diseases including cancer, Alzheimer’s, clinical depression, and irritable bowel syndrome.

The pure CBD tests confirmed the findings of earlier preclinical research. Once again, single-molecule CBD administration generated a bell-shaped dose-response curve with a narrow therapeutic window.

But a different dose response pattern was observed when the clone 202 extract was administered to mice. Rather than showing a bell-shaped curve, where a therapeutic effect could only be achieved at a certain concentration of pure CBD, the whole plant CBD-rich extract caused a direct, dose-dependent inhibition of pain, inflammation, and TNFa production. “In stark contrast to purified CBD,” the Israeli team reported, “the clone extract…provided a clear correlation between the anti-inflammatory and anti-nociceptive responses and the dose, with increasing responses upon increasing doses, which makes this plant medicine ideal for clinical uses.”

“A lot of research has been made to isolate and characterize isolated single constituents of traditional herbal medicine to find their rationale for therapeutic uses,” the Israeli team concluded. “However, our data together with those of others provide legitimation to introduce a new generation of phytopharmaceuticals to treat diseases that have hitherto been treated using synthetic drugs alone. The therapeutic synergy observed with plant extracts results in the requirement for a lower amount of active components, with consequent reduced adverse effects.”

Based on the wonderful feedback we have received from you, our customers, we had little doubt that the truth of the matter would come out in the world of science and are no less shocked it came from nation of Isreal, who have been leading the charge since the 1970's on the amazing potential in cannabinoids for healing medicine.

It is our true purpose and incredible privilege to continue to provide the best medicine we possibly can to improve and extend the lives of the beautiful, loyal, beloved  animals who have enriched all of our lives beyond measure.

-The Highgarden Family

1 Neither did i have proof that talking to my hemp or praying over my plants helped but that didn't stop me :)

2 Link to the published study: